Amy Schumer Breaks Silence on Weight-Loss Medications and Health Battles in Candid Reveal
Amy Schumer is being brutally honest about her health and weight-loss journey as she heads into 2026. The 44-year-old comedian opened up about the challenges she faced with medications, genetics, and serious health conditions, emphasizing the importance of sharing the real story behind her results. Sources for this information include her recent interviews and appearances on Watch What Happens Live and updates on her social media accounts.
Schumer revealed that her experience with popular GLP-1 medications, including Wegovy and Ozempic, was far from easy. I was puking. I couldn’t handle it, she admitted, describing how the nausea made it impossible to spend time with her son. I was one of those people that felt so sick and couldn’t play with my son, she explained. Despite losing 30 pounds quickly, she called the side effects “not livable” and eventually stopped the treatments.
The comedian later learned that her struggles weren’t just random. She has a genetic variant in the GDF15 gene, which makes her highly prone to nausea. This same gene had caused her severe illness during pregnancy, making Ozempic’s side effects feel like being bedridden. I looked great, but I couldn’t lift my head off the pillow. So what’s the point? she said. Eventually, she found a better solution with Mounjaro, which helped her manage her weight without the intense sickness.
Schumer’s health journey didn’t stop there. In early 2024, she was diagnosed with Cushing syndrome, a condition caused by excess cortisol. The disease led to a noticeably “puffy face,” which drew online criticism. I had a disease that makes your face extremely puffy that can kill you but the internet caught it and that disease has been cleared, she shared in December 2025. Today, she manages her health with Mounjaro and hormone treatments for pre-menopause symptoms.
Professionally, Schumer is experiencing a major comeback. Her Netflix comedy Kinda Pregnant, released in February 2025, became one of the platform’s biggest hits, drawing over 25 million views in its first week. She starred alongside Jillian Bell and Will Forte, playing a woman who fakes a pregnancy to gain social status. Schumer described the project as her “return to movies.”
Looking ahead, she plans to focus on self-care while staying active in entertainment. Her Hulu series Life & Beth concluded after two seasons, but she continues to develop a mother-daughter comedy with Paul Feig and is set to appear in the A24 drama The Humans. She also continues touring her stand-up act, which she calls a way to share her “brutal honesty” with fans.
Schumer has been critical of how some celebrities talk about weight loss. Like shut the f*** up. You are on Ozempic or one of those things or you got work done. Just stop, she said, urging others to be honest. For her, the goal is simple: staying healthy enough to play tag with her son without being weighed down by internet criticism.
Amy’s openness about medications, genetics, and health struggles offers a rare glimpse into the real challenges behind celebrity weight loss. It also shows the physical and emotional effort it takes to balance health, family, and career.
What do you think about Amy Schumer calling out other celebrities for not being honest about their weight-loss methods? Share your thoughts in the comments .
